L-methylfolate supplementation in Major Depression patients

A recent article published in The American Journal of Psychiatry describes two studies to investigate the effect of L-methylfolate supplementation in Major Depression patients who are non responders to selective serotonin reuptake inhibitors (SSRIs).Positive response rate and change in depression symptom score were found in the study in which these patients, in addition to SSRIs, received L-methylfolate 15 mg/day for 60 days, compared to those receiving placebo.

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